The cancer-testis antigen FBXO39 predicts poor prognosis and is associated with stemness and aggressiveness in glioma

Jianfeng Wu; Fei Yao; Yuxuan Li; Zhiwei Zhao; Jin Liu; Tianqi Xu; Jia Chai; Yanru Yang; Junyang Song; Chuntao Tian; Qingge Jia; Mingyang Li; Lingfei Li

doi:10.1016/j.prp.2022.154168

The cancer-testis antigen FBXO39 predicts poor prognosis and is associated with stemness and aggressiveness in glioma

Pathol Res Pract. 2022 Nov:239:154168. doi: 10.1016/j.prp.2022.154168. Epub 2022 Oct 13.

Authors

Jianfeng Wu¹, Fei Yao², Yuxuan Li¹, Zhiwei Zhao³, Jin Liu¹, Tianqi Xu¹, Jia Chai¹, Yanru Yang¹, Junyang Song¹, Chuntao Tian⁴, Qingge Jia⁵, Mingyang Li⁶, Lingfei Li⁷

Affiliations

¹ State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
² Military Medicine and Special Subject, No. 971 Hospital of the PLA Navy, Qingdao, China.
³ Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
⁴ Department of Oncology, The Sanmenxia Central Hospital, Sanmenxia, China. Electronic address: 43tct@sina.com.
⁵ Department of Reproductive Endocrinology, Xi'an International Medical Center, Northwest University, Xi'an, China. Electronic address: 361400283@qq.com.
⁶ State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, China. Electronic address: limingyang1108@sina.com.
⁷ State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, China. Electronic address: xbackLayllf@163.com.

PMID: 36244247
DOI: 10.1016/j.prp.2022.154168

Abstract

Gliomas are common brain tumors with poor prognosis. F-box protein39 (FBXO39) is found to be increased in a variety of malignancies, but its expression in gliomas is unknown. Here, we report that FBXO39 as an oncogene is upregulated in glioma and associated with poor prognosis. The degree of FBXO39 positive expression is doubtlessly concomitant with the grade of glioma. The data analyses show that patients with high FBXO39 expression have poor overall survival. What's more, FBXO39 accelerates the invasion and migration abilities of glioma cells and promotes glioma stem cell growth and stemness. In summary, these results suggest that FBXO39 is expected to become a new biological target for judging the prognosis and treatment of glioma.

Keywords: Aggressiveness; FBXO39; Glioma; Prognosis factor; Stemness.

MeSH terms

Brain Neoplasms* / pathology
Cell Proliferation
F-Box Proteins*
Glioma* / pathology
Humans
Male
Prognosis

Substances

F-Box Proteins
FBXO39 protein, human