Diverse approaches have been explored as chromatographic supports for chiral stationary phases (CSPs) in liquid chromatography (LC), such as the introduction of nanoparticles, superficially porous particles, and new materials including monoliths, metal-organic frameworks, covalent-organic frameworks as well as hybrid chromatographic supports. Nevertheless, silica-based CSPs are still nowadays the most successfully and widely applied. In this review, the most relevant achievements related with chromatographic supports used for development of CSPs for LC are described. The advantages and drawbacks of the different materials used as chromatographic supports are critically discussed. Some recent examples of applications are also presented, emphasizing innovative trends in LC.
Keywords: Covalent-organic frameworks; Metal-organic frameworks; Monoliths; Nanomaterials; Superficially porous.
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