An Overview of Class II Phosphoinositide 3-Kinases

Emily Yan Zhi Heng; Tania Maffucci

doi:10.1007/978-3-031-06566-8_2

An Overview of Class II Phosphoinositide 3-Kinases

Curr Top Microbiol Immunol. 2022:436:51-68. doi: 10.1007/978-3-031-06566-8_2.

Authors

Emily Yan Zhi Heng¹, Tania Maffucci²

Affiliations

¹ Centre for Cell Biology and Cutaneous Research, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
² Centre for Cell Biology and Cutaneous Research, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK. t.maffucci@qmul.ac.uk.

PMID: 36243839
DOI: 10.1007/978-3-031-06566-8_2

Abstract

Phosphoinositide 3-kinases (PI3Ks) catalyse the synthesis of specific members of the family of lipids collectively known as 'phosphoinositides'. These PI3Ks products can in turn modulate activation of many downstream proteins, ultimately regulating several cellular processes. Mammalian cells possess eight PI3Ks which are grouped into three classes based on their structure and substrate specificity. While class I and III PI3Ks have been extensively investigated, our understanding of the three class II members has only improved in most recent years. This chapter will summarise some of the available information on mammalian class II PI3Ks and their physiological roles.

Keywords: PI3K-C2α; PI3K-C2β; PI3K-C2γ; Phosphoinositide 3-kinases; Trafficking.

MeSH terms

Class II Phosphatidylinositol 3-Kinases* / genetics
Class II Phosphatidylinositol 3-Kinases* / metabolism
Phosphatidylinositol 3-Kinases* / genetics
Phosphatidylinositol 3-Kinases* / metabolism
Phosphatidylinositols

Substances

Phosphatidylinositols
Class II Phosphatidylinositol 3-Kinases