Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs

Shiyong Teng; Yandong Han; Yang Hu; Jinshuo Li; Min Wang; Zilong Guo; Wensheng Yang

doi:10.1016/j.jcis.2022.10.017

Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs

J Colloid Interface Sci. 2023 Jan 15;630(Pt A):266-273. doi: 10.1016/j.jcis.2022.10.017. Epub 2022 Oct 10.

Authors

Shiyong Teng¹, Yandong Han², Yang Hu³, Jinshuo Li³, Min Wang³, Zilong Guo⁴, Wensheng Yang⁵

Affiliations

¹ Department of Anesthesiology, First Hospital, Jilin University, Changchun 130021, China; State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
² Institute of Molecular Plus, Tianjin University, Tianjin 300072, China.
³ State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
⁴ Institute of Molecular Plus, Tianjin University, Tianjin 300072, China. Electronic address: gzl881101@163.com.
⁵ State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: wsyang@jlu.edu.cn.

PMID: 36242886
DOI: 10.1016/j.jcis.2022.10.017

Abstract

As a new kind of drug carrier, practical applications of hollow periodic mesoporous organosilica (HPMO) have been greatly limited by their low loading capacity for hydrophobic drugs. In this work, we demonstrated the preparation of HPMO capsules with tunable shell thickness by using 1,2-bis(triethoxysilyl)ethane as the precursor. The capsules with thin shells and thus low Young's modulus showed excellent swellability to organic solvents containing hydrophobic drugs. As a result, hydrophobic drugs, i.e., paclitaxel (PTX) could be loaded into the hollow interior of the HPMO capsules with 4 nm shell at an efficiency of ca. 120 %. The as-prepared PTX-loaded HPMO capsules were dispersible in aqueous media and showed improved performance in killing cancer cells compared to free PTX.

Keywords: Capsules; Hollow; Hydrophobic drugs; Organosilica; Swellable.

MeSH terms

Capsules
Drug Carriers / chemistry
Hydrophobic and Hydrophilic Interactions
Organosilicon Compounds* / chemistry
Paclitaxel / pharmacology

Substances

Organosilicon Compounds
Drug Carriers
Paclitaxel
Capsules