Research priorities for measuring biologic age: summary and future directions from the Research Centers Collaborative Network Workshop

Tina E Brinkley; Jamie N Justice; Shubhashrita Basu; Scott R Bauer; Kah Poh Loh; Peter Mukli; Ted Kheng Siang Ng; Indira C Turney; Luigi Ferrucci; Steven R Cummings; Stephen B Kritchevsky

doi:10.1007/s11357-022-00661-w

Research priorities for measuring biologic age: summary and future directions from the Research Centers Collaborative Network Workshop

Geroscience. 2022 Dec;44(6):2573-2583. doi: 10.1007/s11357-022-00661-w. Epub 2022 Oct 15.

Authors

Affiliations

¹ Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA. tbrinkle@wakehealth.edu.
² Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
³ Center for Demography of Health and Aging, University of Wisconsin, Madison, WI, USA.
⁴ Departments of Medicine and Urology, University of California and San Francisco VA Medical Center, San Francisco, CA, USA.
⁵ Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, James P. Wilmot Cancer Institute, Rochester, NY, USA.
⁶ Department of Biochemistry/Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
⁷ Edson College of Nursing and Health Innovation, Arizona State University, Tempe, AZ, USA.
⁸ Department of Neurology, Columbia University Medical Center, New York City, NY, USA.
⁹ Intramural Research Program of the National Institute On Aging, NIH, Baltimore, MD, USA.
¹⁰ San Francisco Coordinating Center, California Pacific Medical Center Research Institute and the Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.

Abstract

Biologic aging reflects the genetic, molecular, and cellular changes underlying the development of morbidity and mortality with advancing chronological age. As several potential mechanisms have been identified, there is a growing interest in developing robust measures of biologic age that can better reflect the underlying biology of aging and predict age-related outcomes. To support this endeavor, the Research Centers Collaborative Network (RCCN) conducted a workshop in January 2022 to discuss emerging concepts in the field and identify opportunities to move the science forward. This paper presents workshop proceedings and summarizes the identified research needs, priorities, and recommendations for measuring biologic age. The highest priorities identified were the need for more robust measures, longitudinal studies, multidisciplinary collaborations, and translational approaches.

Keywords: Aging; Biologic age; Clinical trials; Epigenetics; Multidisciplinary studies.

Publication types

Congress
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Biological Products*
Research*

Substances

Biological Products

Abstract

Publication types

MeSH terms

Substances

Grants and funding