MTRRE-Net: A deep learning model for detection of breast cancer from histopathological images

Comput Biol Med. 2022 Nov:150:106155. doi: 10.1016/j.compbiomed.2022.106155. Epub 2022 Sep 30.

Abstract

Histopathological image classification has become one of the most challenging tasks among researchers due to the fine-grained variability of the disease. However, the rapid development of deep learning-based models such as the Convolutional Neural Network (CNN) has propelled much attentiveness to the classification of complex biomedical images. In this work, we propose a novel end-to-end deep learning model, named Multi-scale Dual Residual Recurrent Network (MTRRE-Net), for breast cancer classification from histopathological images. This model introduces a contrasting approach of dual residual block combined with the recurrent network to overcome the vanishing gradient problem even if the network is significantly deep. The proposed model has been evaluated on a publicly available standard dataset, namely BreaKHis, and achieved impressive accuracy in overcoming state-of-the-art models on all the images considered at various magnification levels.

Keywords: Breast cancer classification; Deep learning; Dual residual network; Histopathological image; Multi-scale features; Recurrent connection.

MeSH terms

  • Breast / pathology
  • Breast Neoplasms* / diagnostic imaging
  • Breast Neoplasms* / pathology
  • Deep Learning*
  • Female
  • Humans
  • Neural Networks, Computer