Ehlers-Danlos syndromes and their manifestations in the visual system

Samuel Asanad; May Bayomi; Douglas Brown; Joshua Buzzard; Eric Lai; Carlthan Ling; Trisha Miglani; Taariq Mohammed; Joby Tsai; Olivia Uddin; Eric Singman

doi:10.3389/fmed.2022.996458

Ehlers-Danlos syndromes and their manifestations in the visual system

Front Med (Lausanne). 2022 Sep 27:9:996458. doi: 10.3389/fmed.2022.996458. eCollection 2022.

Authors

Affiliations

¹ University of Maryland School of Medicine, Department of Ophthalmology & Visual Sciences, Baltimore, MD, United States.
² University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States.

Abstract

Ehlers-Danlos syndrome (EDS) is a rare, genetically variable, heterogenous group of (currently recognized) thirteen connective tissue disorders characterized by skin hyperextensibility, tissue fragility, and generalized joint hypermobility. In addition to these commonly recognized phenotypes, recent studies have notably highlighted variable ophthalmic features in EDS. In this review, we comprehensively gather and discuss the ocular manifestations of EDS and its thirteen subtypes in the clinical setting.

Keywords: Ehlers-Danlos syndrome; eye; neurologic manifestation; ocular manifestation; ocular manifestations; ophthalmology; visual system.

Publication types

Review