Effect of lymph node resection on prognosis of resectable intrahepatic cholangiocarcinoma: A systematic review and meta-analysis

Feiyu Li; Yong Jiang; Liyong Jiang; Qingbin Li; Xiangyu Yan; Songhan Huang; Ji Chen; Shuai Yuan; Yingda Fu; Jun Liu

doi:10.3389/fonc.2022.957792

Effect of lymph node resection on prognosis of resectable intrahepatic cholangiocarcinoma: A systematic review and meta-analysis

Front Oncol. 2022 Sep 27:12:957792. doi: 10.3389/fonc.2022.957792. eCollection 2022.

Authors

Feiyu Li¹, Yong Jiang¹, Liyong Jiang¹, Qingbin Li², Xiangyu Yan¹, Songhan Huang¹, Ji Chen², Shuai Yuan², Yingda Fu¹, Jun Liu¹

Affiliations

¹ Shandong Provincial Hospital, Shandong University, Jinan, China.
² Shandong Provincial Hospital, Shandong First Medical University, Jinan, China.

Abstract

Background: The purpose of this meta-analysis was to evaluate the efficacy of lymph node dissection in patients with intrahepatic cholangiocarcinoma (ICC).

Methods: The literature from January 2009 to December 2021 was searched to determine the comparative study of lymph node dissection and non-lymph node dissection in patients with ICC.

Results: Seventeen studies were included in the analysis. There were no significant differences in 1-, 3-, and 5-year overall survival (OR = 0.80, p = 0.10; OR = 0.93, p = 0.71; OR = 0.80, p = 0.21) and 1-, 3-, and 5-year disease-free survival (OR = 0.89, p = 0.73; OR = 0.92, p = 0.81; OR = 0.85, p = 0.62).

Conclusions: Lymph node dissection does not seem to have a positive effect on the overall survival and disease-free survival.

Keywords: disease-free survival; intrahepatic cholangiocarcinoma; lymph node; overall survival; prognosis.

Publication types

Review