Carboxymethyl cellulose, the most promising cellulose-derivatives, pulls together low cost, abundancy, biocompatibility, unique properties and, unlike the precursor, chemical reactivity. This latter aspect arouses the curiosity of chemists around the possibility of chemical modification and the production of interesting functional materials. Here, a two-step reaction is proposed for the covalent anchoring of a wide variety of molecules containing sulfonic groups to CMC. The strength points of the proposed pathway have to be found in the quick and easy reactions and workup that allow to obtain ready-to-use functional materials with very high yields. Having in this case exploited a pH-sensitive dye as a sulfonated molecule, the functional material is an interesting candidate for the development of colorimetric miniaturized sensors via the following drop-casting deposition: once optimized sensors preparation by design of experiments, an example of application on real samples is reported.
Keywords: CMC; biocompatible materials; colorimetric sensors; covalent grafting; design of experiments; sulfonated dyes.