Holmium Complex with Phospholipids as 1H NMR Relaxational Sensor of Temperature and Viscosity

Olga Yu Selyutina; Sergei P Babailov

doi:10.3390/molecules27196691

Holmium Complex with Phospholipids as ¹H NMR Relaxational Sensor of Temperature and Viscosity

Molecules. 2022 Oct 8;27(19):6691. doi: 10.3390/molecules27196691.

Authors

Olga Yu Selyutina^{1

2}, Sergei P Babailov³

Affiliations

¹ Institute of Chemical Kinetics and Combustion, Institutskaya St. 3, 630090 Novosibirsk, Russia.
² Institute of Solid State Chemistry and Mechanochemistry, Kutateladze St. 18, 630128 Novosibirsk, Russia.
³ A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, Av. Lavrentyev 3, 630090 Novosibirsk, Russia.

Abstract

The sensitivity of Ho-phospholipid complexes to changes in the membrane viscosity of liposomes was checked. An increase in viscosity was observed for DPPC and DMPC near the phase-transition temperature. Ho-phospholipid complexes could be used as sensors of local membrane viscosity in NMR and MRI technologies.

Keywords: NMR; lanthanides; lipid membrane; membrane viscosity sensor; paramagnetic shift.

MeSH terms

Dimyristoylphosphatidylcholine / chemistry
Holmium
Lipid Bilayers / chemistry
Liposomes* / chemistry
Magnetic Resonance Imaging
Phospholipids* / chemistry
Proton Magnetic Resonance Spectroscopy
Temperature
Viscosity

Substances

Lipid Bilayers
Liposomes
Phospholipids
Dimyristoylphosphatidylcholine
Holmium

Grants and funding

20-63-46026/Russian Science Foundation