Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has been widely recognized in numerous studies for its performance of wound healing and regeneration in dentistry. However, bibliometric analysis of PRF in dentistry is still scarce. Thus, this study aimed to conduct and delineate a bibliometric analysis of the application of PRF and its changing trend in dentistry. All papers concerning PRF up to 30 June 2022 were included in the literature search from the Web of Science Core Collection database. These data were then entered into Microsoft Excel, analyzed by the SAS statistical software, and visualized by the VOSviewer software. A total of 562 articles were retrieved following the exclusive criteria. The results demonstrated that the trend of annual publication increased continually (p for trend < 0.01), more notably in the last five years. The majority of the articles were original (58.01%), followed by reviews (17.08%), and case reports (10.14%). The three major study designs were clinical studies (20.11%), randomized controlled trials (17.62%), and review/meta-analysis (17.08%). PRF was most frequently employed in oral surgery (31.14%), periodontal regeneration (22.42%), and implant therapy (18.68%). Turkey (16.19%), India (12.28%) and China (7.12%) were the top 3 countries publishing PRF studies. By comparing the total number of publications, total citation counts and varying counting methods, a combination of numerous counting methods was suggested for use since each counting method yields different results. Taken together, we hope with these informative findings, researchers could focus on the future direction or advancement in PRF, laying a foundation for evidence-based dentistry.
Keywords: bibliometric analysis; dentistry; growth factors; oral surgery; platelet-rich fibrin; wound healing.