Single Cell RNA Sequencing: A New Frontier in Pancreatic Ductal Adenocarcinoma

Maroun Bou Zerdan; Malek Shatila; Dhruv Sarwal; Youssef Bouferraa; Morgan Bou Zerdan; Sabine Allam; Merima Ramovic; Stephen Graziano

doi:10.3390/cancers14194589

Single Cell RNA Sequencing: A New Frontier in Pancreatic Ductal Adenocarcinoma

Cancers (Basel). 2022 Sep 22;14(19):4589. doi: 10.3390/cancers14194589.

Authors

Maroun Bou Zerdan¹, Malek Shatila², Dhruv Sarwal¹, Youssef Bouferraa³, Morgan Bou Zerdan⁴, Sabine Allam⁴, Merima Ramovic⁵, Stephen Graziano⁵

Affiliations

¹ Department of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
² Department of Gastroenterology, Hepatology & Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
³ Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44118, USA.
⁴ Faculty of Medicine, University of Balamand, Beirut 0000, Lebanon.
⁵ Department of Hematology and Oncology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Abstract

Pancreatic ductal adenocarcinoma is a malignancy with a high mortality rate. It exhibits significant heterogeneity in metabolic pathways which are associated with its progression. In this review, we discuss the role of single cell RNA sequencing in unraveling the metabolic and clinical features of these highly malignant tumors.

Keywords: fibroblasts; pancreatic ductal adenocarcinoma; single cell RNA sequencing; transcriptomes.

Publication types

Review

Grants and funding

This research received no external funding.