Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine

Antonio G Goncalves; Emily J Hartzell; Millicent O Sullivan; Wilfred Chen

doi:10.1016/j.addr.2022.114570

Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine

Adv Drug Deliv Rev. 2022 Dec:191:114570. doi: 10.1016/j.addr.2022.114570. Epub 2022 Oct 10.

Authors

Antonio G Goncalves¹, Emily J Hartzell¹, Millicent O Sullivan², Wilfred Chen³

Affiliations

¹ Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States.
² Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States. Electronic address: msullivan@udel.edu.
³ Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States. Electronic address: wilfred@udel.edu.

PMID: 36228897
DOI: 10.1016/j.addr.2022.114570

Abstract

Currently, there are over 100 antibody-based therapeutics on the market for the treatment of various diseases. The increasing importance of antibody treatment is further highlighted by the recent FDA emergency use authorization of certain antibody therapies for COVID-19 treatment. Protein-based materials have gained momentum for antibody delivery due to their biocompatibility, tunable chemistry, monodispersity, and straightforward synthesis and purification. In this review, we discuss progress in engineering the molecular features of protein-based biomaterials, in particular recombinant protein polymers, for introducing novel functionalities and enhancing the delivery properties of antibodies and related binding protein domains.

Publication types

Review
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antibodies
Biocompatible Materials / chemistry
COVID-19 Drug Treatment*
Humans
Nanotechnology
Polymers* / chemistry
Recombinant Proteins

Substances

Polymers
Biocompatible Materials
Recombinant Proteins
Antibodies