Critical functions of N6-adenosine methylation of mRNAs in T cells

Taku Ito-Kureha; Vigo Heissmeyer

doi:10.1016/j.bbamcr.2022.119380

Critical functions of N⁶-adenosine methylation of mRNAs in T cells

Biochim Biophys Acta Mol Cell Res. 2023 Jan;1870(1):119380. doi: 10.1016/j.bbamcr.2022.119380. Epub 2022 Oct 11.

Authors

Taku Ito-Kureha¹, Vigo Heissmeyer²

Affiliations

¹ Institute for Immunology, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, 82152 Planegg-Martinsried, Germany. Electronic address: Taku.Kureha@med.uni-muenchen.de.
² Institute for Immunology, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, 82152 Planegg-Martinsried, Germany; Research Unit Molecular Immune Regulation, Helmholtz Zentrum München, 81377 Munich, Germany. Electronic address: Vigo.Heissmeyer@med.uni-muenchen.de.

PMID: 36228837
DOI: 10.1016/j.bbamcr.2022.119380

Abstract

The existence of N⁶-adenosine methylation (m⁶A) of mRNA has been known for a long time, but only recently its regulatory potential was uncovered. Current research deciphers the molecular determinants leading to the deposition of this modification and consequences for modified mRNAs. It also evaluates the importance of such modifications for specific cell types and programs. In this review, we summarize the current knowledge on m⁶A modification of mRNAs in conventional and regulatory T cells and T-cell-driven immune responses and pathology. We discuss the impact of m⁶A modification on T cell activation including cytokine and antigen receptor signaling or sensing of double-stranded RNAs (dsRNA).

Keywords: Epitranscriptomics; T cell; TCR signaling; m6A.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine* / genetics
Methylation
RNA, Messenger / genetics
RNA, Messenger / metabolism
T-Lymphocytes* / metabolism

Substances

N(6)-ribosyladenine
RNA, Messenger
Adenosine