Discovery of a genome-wide significant locus associated with antidepressant response in Han Chinese population

Jing Yuan; Chu-Yi Zhang; Li Xu; Lu Wang; Yan Zhang; Yu-Jun Wei; Xin Wang; Yue Xu; Li-Mei Feng; Xiao Xiao; Lei Wu; Chuan-Yuan Kang; Jian-Zhong Yang

doi:10.1016/j.ajp.2022.103294

Discovery of a genome-wide significant locus associated with antidepressant response in Han Chinese population

Asian J Psychiatr. 2022 Dec:78:103294. doi: 10.1016/j.ajp.2022.103294. Epub 2022 Oct 8.

Authors

Jing Yuan¹, Chu-Yi Zhang², Li Xu¹, Lu Wang², Yan Zhang¹, Yu-Jun Wei¹, Xin Wang¹, Yue Xu¹, Li-Mei Feng³, Xiao Xiao², Lei Wu¹, Chuan-Yuan Kang⁴, Jian-Zhong Yang⁵

Affiliations

¹ Department of Psychiatry, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
² Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
³ Department of Pharmacy, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
⁴ Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: kangchuanyuan@tongji.edu.cn.
⁵ Department of Psychiatry, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. Electronic address: yangjianzhong@kmmu.edu.cn.

PMID: 36228427
DOI: 10.1016/j.ajp.2022.103294

No abstract available

Keywords: Genome-wide association study; Han Chinese population; Major depressive disorder; Polygenic risk score; Response to antidepressant treatment.

Publication types

Letter

MeSH terms

Antidepressive Agents / pharmacology
Antidepressive Agents / therapeutic use
Asian People* / genetics
Case-Control Studies
China
Genetic Predisposition to Disease*
Humans
Polymorphism, Single Nucleotide

Substances

Antidepressive Agents