Complete Genome Sequence of a New Zealand Mycobacterium tuberculosis Strain Responsible for Ongoing Transmission over the Past 30 Years

Claire V Mulholland; Gregory Gimenez; Adele Williamson; Mackenzie Steele; Duncan Thorpe; Noel Karalus; Ray T Cursons; Veronica M Playle; Sally A Roberts; Gregory M Cook; Vickery L Arcus; Htin Lin Aung

doi:10.1128/mra.00781-22

Complete Genome Sequence of a New Zealand Mycobacterium tuberculosis Strain Responsible for Ongoing Transmission over the Past 30 Years

Microbiol Resour Announc. 2022 Nov 17;11(11):e0078122. doi: 10.1128/mra.00781-22. Epub 2022 Oct 13.

Authors

Claire V Mulholland^#^{1

2}, Gregory Gimenez^#³, Adele Williamson¹, Mackenzie Steele¹, Duncan Thorpe⁴, Noel Karalus⁴, Ray T Cursons¹, Veronica M Playle^{5

6

2}, Sally A Roberts^{6

2}, Gregory M Cook^{7

2}, Vickery L Arcus^{1

2}, Htin Lin Aung^{7

2}

Affiliations

¹ School of Science, University of Waikato, Hamilton, New Zealand.
² Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
³ Department of Pathology, Dunedin School of Medicine, Dunedin, New Zealand.
⁴ Department of Pathology, Waikato Hospital, Waikato District Health Board, Hamilton, New Zealand.
⁵ Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
⁶ LabPlus, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand.
⁷ Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

^# Contributed equally.

Abstract

We report here the complete genome sequence of Mycobacterium tuberculosis strain Colonial S-type 1 (CS1), which has been responsible for ongoing outbreaks of tuberculosis in New Zealand over the past 30 years. CS1 appears to be highly transmissible, with greater rates of progression to active disease, compared to other circulating M. tuberculosis strains; therefore, comparison of its genomic content is of interest.