The emerging role of long non-coding RNAs in schizophrenia

Guangxian Wu; Xinzhe Du; Zexuan Li; Yanhong Du; Jinzhi Lv; Xinrong Li; Yong Xu; Sha Liu

doi:10.3389/fpsyt.2022.995956

The emerging role of long non-coding RNAs in schizophrenia

Front Psychiatry. 2022 Sep 26:13:995956. doi: 10.3389/fpsyt.2022.995956. eCollection 2022.

Authors

Guangxian Wu^{1

2}, Xinzhe Du^{1

3}, Zexuan Li^{1

3}, Yanhong Du^{1

3}, Jinzhi Lv^{1

2}, Xinrong Li³, Yong Xu^{1

4}, Sha Liu^{1

3}

Affiliations

¹ Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China.
² Department of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China.
³ Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China.
⁴ Department of Mental Health, Shanxi Medical University, Taiyuan, China.

Abstract

Schizophrenia (SZ) is a severe psychiatric disorder which is contributed by both genetic and environmental factors. However, at present, its specific pathogenesis is still not very clear, and there is a lack of objective and reliable biomarkers. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involved in the pathophysiology of several psychiatric disorders, including SZ, and hold promise as potential biomarkers and therapeutic targets for psychiatric disorders. In this review, we summarize and discuss the role of lncRNAs in the pathogenesis of SZ and their potential value as biomarkers and therapeutic targets.

Keywords: biomarker; long non-coding RNAs; pathophysiology; schizophrenia; therapy.

Publication types

Review