Isatropolone/isarubrolone Cm from Streptomyces with biological activity of inducing incomplete autophagy

Abstract

Isatropolones/isarubrolones are Streptomyces secondary metabolites featuring a tropolone ring in the pentacyclic scaffolds of these molecules. They are able to induce complete autophagy in human HepG2 cells. Here, methyl isatropolones (1-2) and isarubrolone (3) are identified from Streptomyces CPCC 204095. They all have a methyl tropolone ring in the pentacyclic scaffold of these molecules resolved by MS and NMR spectra. Biological activity assay indicates that isatropolone C_m (1) and isarubrolone C_m (3) induce incomplete autophagy in human HepG2 cells.