The SARS-CoV-2 specific IgG antibodies biophotonic sensor

Małgorzata Szczerska; Paweł Wityk; Paulina Listewnik

doi:10.1002/jbio.202200172

The SARS-CoV-2 specific IgG antibodies biophotonic sensor

J Biophotonics. 2023 Jan;16(1):e202200172. doi: 10.1002/jbio.202200172. Epub 2022 Oct 19.

Authors

Małgorzata Szczerska¹, Paweł Wityk², Paulina Listewnik¹

Affiliations

¹ Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, Gdańsk, Poland.
² Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland.

Abstract

In this paper, we present the design and the principle of operation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific immunoglobulin G (IgG) biophotonic sensor, which is based on the single-mode telecommunication fiber. We fabricated the sensor head at the face of the single mode fiber-28. Due to the process of bio-functionalization, our sensor has the ability to selectively detect the SARS-CoV-2 specific IgG antibodies. The results of preliminary tests allowed us to correctly determine the presence of antibodies in less than 1 min in 5 μl in a volume sample of concentration of 10 μg/ml, which according to studies, corresponds to the concentration of IgG antibodies in human serum. Additionally, the tested sample can be smaller than 5 μl in volume.

Keywords: biophotonics; fiber-optic sensorIgGimmunosensorSARS-CoV-2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral
COVID-19*
Humans
Immunoglobulin G
SARS-CoV-2*

Substances

Immunoglobulin G
Antibodies, Viral