Optical coherence tomography (OCT), a promising noninvasive bioimaging technique, can resolve sample three-dimensional microstructures. However, speckle noise imposes obvious limitations on OCT resolving capabilities. Here we proposed a deep-learning-based speckle-modulating OCT based on a hybrid-structure network, residual-dense-block U-Net generative adversarial network (RDBU-Net GAN), and further conducted a comprehensively comparative study to explore multi-type deep-learning architectures' abilities to extract speckle pattern characteristics and remove speckle, and resolve microstructures. This is the first time that network comparative study has been performed on a customized dataset containing mass more-general speckle patterns obtained from a custom-built speckle-modulating OCT, but not on retinal OCT datasets with limited speckle patterns. Results demonstrated that the proposed RDBU-Net GAN has a more excellent ability to extract speckle pattern characteristics and remove speckle, and resolve microstructures. This work will be useful for future studies on OCT speckle removing and deep-learning-based speckle-modulating OCT.