Managing the health and safety risks surrounding COVID-19 in congregate settings, such as on college campuses, and minimizing viral transmission should be on the dashboard of Higher Education Leadership. Understanding that the risk will not be zero, like other academic institutions, Historically Black Colleges and Universities (HBCUs) have given great thought to making their campuses, which are considered high-risk settings, safe enough to warrant returning to campus. We queried HBCU leadership via an online survey sent to all 102 HBCUs about their safety plan for the fall 2020 resumption of on-campus activities. While data show that there are 102 HBCUs, we were informed that two HBCUs were permanently closed during our data gathering period. Thus, the sample size was 100. Specific areas queried included risks management plans, mitigation steps, policy changes, and human capacity resources. We also asked these leaders to identify vulnerabilities and other factors they considered in planning a safe reopening. Findings indicated that as these academic institutions grappled with balancing between risks and benefits of reopening, they also had to recognize the numerous scenarios and multifaceted approaches required. Recommendations are presented for supporting HBCUs in the future to surmount obstacles and implement culturally responsive solutions that best serve their campuses and surrounding communities in which these academic institutions are anchored.