Post-acute anti-NMDAR encephalitis mirrors schizophrenia

Sergio Muñiz-Castrillo; Alberto Vogrig; Jérôme Honnorat

doi:10.1016/j.molmed.2022.09.010

Post-acute anti-NMDAR encephalitis mirrors schizophrenia

Trends Mol Med. 2022 Nov;28(11):895-896. doi: 10.1016/j.molmed.2022.09.010. Epub 2022 Oct 8.

Authors

Sergio Muñiz-Castrillo¹, Alberto Vogrig², Jérôme Honnorat³

Affiliations

¹ French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Lyon, France; MeLiS - UCBL-CNRS UMR 5284 - INSERM U1314, Université Claude Bernard Lyon 1, Lyon, France; Stanford Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA.
² French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Lyon, France; MeLiS - UCBL-CNRS UMR 5284 - INSERM U1314, Université Claude Bernard Lyon 1, Lyon, France; Clinical Neurology, Santa Maria Della Misericordia University Hospital, Azienda Ospedaliera Universitaria Friuli Centrale (ASU FC), Udine, Italy.
³ French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Lyon, France; MeLiS - UCBL-CNRS UMR 5284 - INSERM U1314, Université Claude Bernard Lyon 1, Lyon, France. Electronic address: jerome.honnorat@chu-lyon.fr.

PMID: 36220717
DOI: 10.1016/j.molmed.2022.09.010

Abstract

The post-acute evolution of the cognitive and psychiatric features of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been poorly investigated so far. In recent work published in Lancet Neurology, Guasp et al. report that the neuropsychiatric symptoms of the post-acute phase mirror those observed in schizophrenia, although only patients with anti-NMDAR encephalitis showed improvements of their symptoms.

Keywords: anti-NMDAR encephalitis; autoimmune psychosis; schizophrenia.

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MeSH terms

Anti-N-Methyl-D-Aspartate Receptor Encephalitis* / diagnosis
Anti-N-Methyl-D-Aspartate Receptor Encephalitis* / etiology
Humans
Schizophrenia* / diagnosis