Challenges and opportunities in C1-based biomanufacturing

Weibo Qiao; Shijie Xu; Zihe Liu; Xiaoying Fu; Huimin Zhao; Shuobo Shi

doi:10.1016/j.biortech.2022.128095

Challenges and opportunities in C1-based biomanufacturing

Bioresour Technol. 2022 Nov:364:128095. doi: 10.1016/j.biortech.2022.128095. Epub 2022 Oct 8.

Authors

Weibo Qiao¹, Shijie Xu¹, Zihe Liu¹, Xiaoying Fu¹, Huimin Zhao², Shuobo Shi³

Affiliations

¹ Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
² Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
³ Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: shishuobo@mail.buct.edu.cn.

PMID: 36220528
DOI: 10.1016/j.biortech.2022.128095

Abstract

The intensifying impact of green-house gas (GHG) emission on environment and climate change has attracted increasing attention, and biorefinery represents one of the most effective routes for reducing GHG emissions from human activities. However, this requires a shift for microbial fermentation from the current use of sugars to the use of biomass, and even better to the primary fixation of single carbon (C1) compounds. Here how microorganisms can be engineered for fixation and conversion of C1 compounds into metabolites that can serve as fuels and platform chemicals are reviewed. Meanwhile, key factors for utilization of these different pathways are discussed, followed by challenges and barriers for the development of C1-based biorefinery.

Keywords: C1-based biorefinery; Metabolic engineering; Metabolic networks and pathways; Synthetic biology.

Publication types

Review