Worm development: Push not pull in gonad morphogenesis

Curr Biol. 2022 Oct 10;32(19):R1007-R1009. doi: 10.1016/j.cub.2022.08.047.

Abstract

How does tissue elongation occur? A recent paper identifies a new mechanism: elongation of the Caenorhabditis elegans hermaphrodite gonad is driven by pressure from proliferating germ cells confined within a tube. The distal tip cell, which caps the tube, remodels the extracellular matrix and adjusts cell-matrix adhesion to guide the way.

MeSH terms

  • Animals
  • Caenorhabditis elegans Proteins* / genetics
  • Caenorhabditis elegans Proteins* / metabolism
  • Caenorhabditis elegans* / metabolism
  • Germ Cells / metabolism
  • Gonads
  • Morphogenesis

Substances

  • Caenorhabditis elegans Proteins