Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor-Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen-Targeting Small Interfering RNA

J Am Heart Assoc. 2022 Oct 18;11(20):e027694. doi: 10.1161/JAHA.122.027694. Epub 2022 Oct 10.
No abstract available

Keywords: angiotensinogen; hypertension therapy; reversibility; siRNA; zilebesiran.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensinogen* / genetics
  • Animals
  • Blood Pressure
  • Humans
  • Hypertension* / drug therapy
  • Hypertension* / genetics
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / pharmacology
  • RNA, Small Interfering / therapeutic use
  • Rats
  • Rats, Inbred SHR
  • Vasoconstrictor Agents / pharmacology

Substances

  • Angiotensinogen
  • RNA, Small Interfering
  • Vasoconstrictor Agents