Cytospones E-J from the endophytic fungus Cytospora rhizophorae

Yanjiang Zhang; Hongxin Liu; Yuchan Chen; Shanshan Wei; Weimin Zhang; Haibo Tan

doi:10.1016/j.fitote.2022.105324

Cytospones E-J from the endophytic fungus Cytospora rhizophorae

Fitoterapia. 2022 Nov:163:105324. doi: 10.1016/j.fitote.2022.105324. Epub 2022 Oct 7.

Authors

Yanjiang Zhang¹, Hongxin Liu², Yuchan Chen², Shanshan Wei¹, Weimin Zhang³, Haibo Tan⁴

Affiliations

¹ Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
² State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, People's Republic of China.
³ State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, People's Republic of China. Electronic address: wmzhang@gdim.cn.
⁴ Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China. Electronic address: tanhaibo@scbg.ac.cn.

PMID: 36216139
DOI: 10.1016/j.fitote.2022.105324

Abstract

Cytospones E-J (1-6), six unreported α-pyrone derivatives, together with six known ones (7-12) were isolated from the solid culture of the endophytic fungus Cytospora rhizophorae A761, an endophytic fungus from Gynochthodes officinalis. The structures of the unreported compounds were unambiguously elucidated through spectroscopic analyses (1D, 2D NMR and HRESIMS), and their absolute configurations were assigned by single-crystal X-ray diffraction (Cu Kα) analyses. Furthermore, cytospones E-J were evaluated for anti-inflammatory and α-glucosidase inhibitory activities.

Keywords: Anti-inflammatory activity; Cytospora rhizophorae; Endophytic fungus; Gynochthodes officinalis; α-Glucosidase inhibitory activity; α-Pyrone.

MeSH terms

Ascomycota* / chemistry
Crystallography, X-Ray
Molecular Structure
Pyrones

Substances

Pyrones

Supplementary concepts

Cytospora rhizophorae