Post-translational modifications and age-related hearing loss

Parveen Bazard; Jennifer Pineros; Alejandro A Acosta; Mark Thivierge; Lauren R Paganella; Samuel Zucker; Freyda L Mannering; Shrikar Modukuri; Xiaoxia Zhu; Robert D Frisina; Bo Ding

doi:10.1016/j.heares.2022.108625

Post-translational modifications and age-related hearing loss

Hear Res. 2022 Dec:426:108625. doi: 10.1016/j.heares.2022.108625. Epub 2022 Sep 25.

Affiliations

¹ Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
² School of Medicine, University of Puerto Rico, San Juan 00925, Puerto Rico; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
³ Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
⁴ Biomedical Sciences - Dept. of Chemistry, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
⁵ Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Department Communication Sciences and Disorders, College of Behavioral & Communication Sciences, Tampa, FL 33620, USA; Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA. Electronic address: rfrisina@usf.edu.

PMID: 36215796
DOI: 10.1016/j.heares.2022.108625

Abstract

Post-translational modifications (PTMs) affect nearly all systems of the human body due to their role in protein synthesis and functionality. These reversible and irreversible modifications control the structure, localization, activity, and properties of proteins. For this reason, PTMs are essential in regulating cellular processes and maintaining homeostasis. Diseases such as Alzheimer's, cardiovascular disease, diabetes, cancer, and many others have been linked to dysfunctions of PTMs. Recent research has also shown that irregularities in PTMs can be linked to hearing loss, including age-related hearing loss (ARHL) - the number one communication disorder and one of the top neurodegenerative diseases in our aging population. So far, there has been no FDA approved treatment for ARHL; however, translational studies investigating PTMs involvement in ARHL show promising results. In this review, we summarize key findings for PTMs within the auditory system, the involvement of PTMs with aging and ARHL, and lastly discuss potential treatment options focusing on utilizing PTMs as biomarkers and therapeutic pathway components.

Keywords: Age-related Hearing Loss; Aging; Auditory system; Cochlea; Inner ear; Neurodegenerative disorders; Post-translational modifications.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Aged
Aging / metabolism
Deafness*
Humans
Presbycusis* / drug therapy
Presbycusis* / therapy
Protein Processing, Post-Translational

Grants and funding

P01 AG009524/AG/NIA NIH HHS/United States