One Hundred Carboxylate Receptors

J Org Chem. 2022 Nov 4;87(21):14186-14193. doi: 10.1021/acs.joc.2c01725. Epub 2022 Oct 10.

Abstract

This work presents a compilation of binding constant (logKass) values in DMSO-d6/H2O (0.5% m/m) for a variety of receptors with 12 carboxylate anions (formate, acetate, lactate, pivalate, sorbate, hexanoate, benzoate, glyphosate, glucuronate, ibuprofen, naproxen, and ketoprofen). A total of 489 logKass values are listed for 100 anion receptor molecules. Most logKass values originate from previously published articles, along with some values for previously unpublished receptor molecules, spanning a workflow of 8 years. The purpose of this study is to serve as a comprehensive information source for selecting suitable receptor candidates to be used in practical carboxylate sensing applications, such as constructing ion-selective electrodes (ISE-s). To support such decision making, all receptors are presented together with lipophilicity (logPo/w) data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anions
  • Carboxylic Acids
  • Ibuprofen / chemistry
  • Ketoprofen* / chemistry
  • Naproxen / chemistry

Substances

  • Anions
  • Carboxylic Acids
  • Ibuprofen
  • Ketoprofen
  • Naproxen