Synergetic reorganization of the contralateral structure and function in patients with unilateral frontal glioma

Honglin Ge; Zheng Yan; Dongming Liu; Wenzhang Qi; Shanshan Chen; Kun Yang; Hongyi Liu; Yuanjie Zou; Xinhua Hu; Yong Liu; Jiu Chen

doi:10.3389/fnins.2022.1016693

Synergetic reorganization of the contralateral structure and function in patients with unilateral frontal glioma

Front Neurosci. 2022 Sep 23:16:1016693. doi: 10.3389/fnins.2022.1016693. eCollection 2022.

Authors

Honglin Ge¹, Zheng Yan¹, Dongming Liu¹, Wenzhang Qi², Shanshan Chen³, Kun Yang¹, Hongyi Liu¹, Yuanjie Zou¹, Xinhua Hu¹, Yong Liu¹, Jiu Chen^{4

5}

Affiliations

¹ Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
² Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
³ Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
⁴ Institute of Neuropsychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
⁵ Institute of Brain Functional Imaging, Nanjing Medical University, Nanjing, China.

Abstract

Objective: This study aimed to investigate the contralateral structural and functional plasticity induced by frontal gliomas.

Methods: Patients with left (n = 49) or right (n = 52) frontal diffuse glioma were enrolled along with 35 age- matched healthy controls (HCs). The gray-matter volumes (GMVs) of the contralesional region were measured using the voxel-based morphometry (VBM) analysis. Additionally, the amplitude of low-frequency fluctuation (ALFF) of the contralesional region was calculated via resting state functional magnetic resonance imaging (MRI) to assess functional alterations.

Result: The GMV of the contralateral orbitofrontal cortex of the right or left frontal gliomas was significantly larger than the corresponding GMV in the controls. In the patients with right frontal glioma, the GMV and ALFF in the left inferior frontal gyrus were significantly increased compared with those in the controls.

Conclusion: Glioma invasion of the frontal lobe can induce contralateral structural compensation and functional compensation, which show synergy in the left inferior frontal gyrus. Our findings explain why patients with unilateral frontal glioma can have functional balance, and offer the possibility of preserving the brain function while maximizing tumor removal.

Keywords: contralateral reorganization; frontal glioma; plasticity; resting-state fMRI; voxel-based morphometry.