Nonpharmacological Strategies in Heart Failure with Preserved Ejection Fraction

Natalie J Bohmke; Hayley E Billingsley; Danielle L Kirkman; Salvatore Carbone

doi:10.1016/j.ccl.2022.06.003

Nonpharmacological Strategies in Heart Failure with Preserved Ejection Fraction

Cardiol Clin. 2022 Nov;40(4):491-506. doi: 10.1016/j.ccl.2022.06.003. Epub 2022 Sep 15.

Authors

Natalie J Bohmke¹, Hayley E Billingsley¹, Danielle L Kirkman², Salvatore Carbone³

Affiliations

¹ Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, 500 Academic Centre, Room 113C 1020 W Grace Street, Richmond, VA 23220, USA; Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, West Hospital 6th Floor, North Wing Box, 980036 Richmond, VA 23298, USA.
² Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, 500 Academic Centre, Room 113C 1020 W Grace Street, Richmond, VA 23220, USA; Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, West Hospital 6th Floor, North Wing Box, 980036 Richmond, VA 23298, USA. Electronic address: dlkirkman@vcu.edu.
³ Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, 500 Academic Centre, Room 113C 1020 W Grace Street, Richmond, VA 23220, USA; Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, West Hospital 6th Floor, North Wing Box, 980036 Richmond, VA 23298, USA. Electronic address: scarbone@vcu.edu.

Abstract

Patients with heart failure with preserved ejection fraction (HFpEF) suffer from a high rate of cardiometabolic comorbidities with limited pharmaceutical therapies proven to improve clinical outcomes and cardiorespiratory fitness (CRF). Nonpharmacologic therapies, such as exercise training and dietary interventions, are promising strategies for this population. The aim of this narrative review is to present a summary of the literature published to date and future directions related to the efficacy of nonpharmacologic, lifestyle-related therapies in HFpEF, with a focus on exercise training and dietary interventions.

Keywords: Caloric restriction; Dietary pattern; Exercise; HFpEF; HIIT training; Malnutrition; Obesity; Sodium restriction.

Publication types

Review

MeSH terms

Exercise Tolerance
Heart Failure* / therapy
Humans
Stroke Volume
Ventricular Function, Left

Grants and funding

UL1 TR002649/TR/NCATS NIH HHS/United States