Multifunctional nanoprobes for macrophage imaging

Hongping Deng; Li Xu; Jingxuan Ju; Xuan Mo; Guangbo Ge; Xinyuan Zhu

doi:10.1016/j.biomaterials.2022.121824

Multifunctional nanoprobes for macrophage imaging

Biomaterials. 2022 Nov:290:121824. doi: 10.1016/j.biomaterials.2022.121824. Epub 2022 Sep 29.

Authors

Hongping Deng¹, Li Xu², Jingxuan Ju³, Xuan Mo³, Guangbo Ge⁴, Xinyuan Zhu⁵

Affiliations

¹ Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: hpdeng@shutcm.edu.cn.
² Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China.
³ Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
⁴ Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: geguangbo@dicp.ac.cn.
⁵ School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: xyzhu@sjtu.edu.cn.

PMID: 36209580
DOI: 10.1016/j.biomaterials.2022.121824

Abstract

Imaging and tracking macrophage behaviors in vivo are essential to reveal its biological function and fate in various diseases. Small molecular probes suffer from poor macrophage targeting and retention, rapid clearance, and deficient metabolizing stability. To overcome these limitations, a variety of functional nanoprobes have been developed for targeted imaging of macrophages in divergent diseases such as cancer, atherosclerosis and obesity. Generally, nanoprobes are functionalized with targeting peptides, ligands or antibodies to fulfill high macrophage affinity. In this review, the most recent advances of nanoprobes for imaging macrophages in vivo and ex vivo are systematically summarized. The challenges and perspectives of precisely imaging macrophages with improved signal-to-background ratios via nanoprobes are further discussed.

Keywords: MRI; Macrophage; Molecular imaging; Optical; PET.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Atherosclerosis*
Diagnostic Imaging
Humans
Macrophages
Molecular Probes
Nanoparticles* / chemistry
Neoplasms*

Substances

Molecular Probes