Cyclophilin D knockout mice do not accumulate succinate during cardiac ischemia

Hiran A Prag; Duvaraka Kula-Alwar; Paolo Bernardi; Fabio Di Lisa; Michael P Murphy; Thomas Krieg

doi:10.1016/j.yjmcc.2022.09.006

Cyclophilin D knockout mice do not accumulate succinate during cardiac ischemia

J Mol Cell Cardiol. 2022 Dec:173:73-74. doi: 10.1016/j.yjmcc.2022.09.006. Epub 2022 Oct 6.

Authors

Hiran A Prag¹, Duvaraka Kula-Alwar², Paolo Bernardi³, Fabio Di Lisa³, Michael P Murphy¹, Thomas Krieg⁴

Affiliations

¹ Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, United Kingdom.
² Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom.
³ Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy; Neuroscience Institute, National Research Council of Italy (CNR), 35131 Padova, Italy.
⁴ Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom. Electronic address: tk382@medschl.cam.ac.uk.

PMID: 36209553
DOI: 10.1016/j.yjmcc.2022.09.006

No abstract available

Keywords: Cyclophilin D; Cyclosporin A; Ischemia/reperfusion injury; Mitochondrial permeability transition pore; Reactive oxygen species; Succinate.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cyclophilins*
Ischemia
Mice
Mice, Knockout
Mitochondrial Membrane Transport Proteins
Peptidyl-Prolyl Isomerase F
Succinic Acid*

Substances

Peptidyl-Prolyl Isomerase F
Succinic Acid
Cyclophilins
Mitochondrial Membrane Transport Proteins

Publication types

MeSH terms

Substances

Grants and funding