The role of exosomes in the tumour microenvironment on macrophage polarisation

Jing Wang; Runmin Long; Yunwei Han

doi:10.1016/j.bbcan.2022.188811

The role of exosomes in the tumour microenvironment on macrophage polarisation

Biochim Biophys Acta Rev Cancer. 2022 Nov;1877(6):188811. doi: 10.1016/j.bbcan.2022.188811. Epub 2022 Oct 5.

Authors

Jing Wang¹, Runmin Long², Yunwei Han³

Affiliations

¹ Department of Blood Transfusion, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China. Electronic address: wangjing088@swmu.edu.cn.
² Southwest Medical University, Luzhou 646000, Sichuan, China.
³ Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.

PMID: 36208648
DOI: 10.1016/j.bbcan.2022.188811

Abstract

Macrophages are highly heterogeneous immune cells that play an important role in the tumour microenvironment (TME). After being stimulated differently in the TME, macrophages can be polarised into the M1 phenotype to exhibit an anti-tumour effect or the M2 phenotype to exhibit a tumour-promoting effect. There are a large number of exosomes in the TME that can transmit information between cells and regulate the polarisation of macrophages, thereby affecting tumour invasion, metastasis, and treatment. This review introduces some of the pathways involved in M1/M2 macrophage polarisation and the effects of substances carried by exosomes from different sources in the TME on macrophage polarisation, especially microRNAs (miRNAs).

Keywords: Exosomes; Macrophages; Polarisation; Tumour microenvironment; miRNA.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Exosomes* / metabolism
Humans
Macrophage Activation
Macrophages
MicroRNAs* / genetics
MicroRNAs* / metabolism
Neoplasms* / metabolism
Tumor Microenvironment

Substances

MicroRNAs