Single-entity collisional electrochemistry (SECE) can capture physicochemical information at the single entity level. In the present work, we systematically studied in-situ generation and detection of single anionic ionosomes via SECE combined with a miniaturized interface between two immiscible electrolyte solutions (ITIES). Ionosome is an ionic-bilayer encapsulated nanoscopic water cluster/droplet that carries a net charge. Discrete spiky ionic currents were observed upon collisions/fusions of individual F- or Cl- -ionosomes with a positively polarized micro-ITIES. This fusion process was proved to follow the bulk electrolysis model. With this method, some essential factors such as concentration and charge density of the hydrated anions, and the interfacial area, were revealed. It demonstrates that anionic ionosomes share a common theoretical framework with their counterparts (i. e., cationic ionosomes, like Li+ -ionosomes). This work will spur the advancements in a myriad of fields, including such as the colloid and interface science, micro- and/or nanoscale electrochemistry, and electrophysiology and brain sciences.
Keywords: ITIES; anionic ionosomes; bulk electrolysis; single-entity collisional electrochemistry.
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