Multiple myeloma (MM) is a common hematologic tumor characterized by malignant proliferation of clonal plasma cells, the exact pathogenesis of which is not yet fully understood. The extracellular vesicles (EV) are structures released by cells into their surroundings that do not have a functional nucleus and can communicate between cells or deliver biologically active proteins and nucleic acids to target cells. EV play an important role in the interaction between myeloma cells and the bone marrow microenvironment, and they can promote MM progression. In this paper, we summarize the recent research progress in the mechanism of action of EV on MM in order to provide inspiration for exploring new strategies for MM treatment and prognostic stratification.
题目: 细胞外囊泡在多发性骨髓瘤中作用机制的研究进展.
摘要: 多发性骨髓瘤（MM）是一种以克隆性浆细胞恶性增殖为特征的常见血液系统肿瘤，其具体发病机制目前尚未完全清晰。细胞外囊泡（EV）是细胞释放到其周围环境中的一种不具有功能性细胞核的结构，可在细胞间通讯或将具有生物活性的蛋白质、核酸传递给靶细胞。EV在MM细胞与骨髓微环境的相互作用中起到了重要的作用，能促进MM进展。本文就EV对MM的作用机制最新研究进展作一综述，以期为MM 治疗及预后分层探索新的策略提供启发.
Keywords: biomarker; extracellular vesicle; multiple myeloma.