Objective: To investigate the status of transfusion-transmissible infection (TTI) among voluntary blood donors in Nanjing in recent five years, in order to provide data support for the recruitment of blood donors and formulation and updating of blood screening strategies.
Methods: HIV/HBV/HCV/TP serological markers were detected by ELISA in 487 120 blood donors in Nanjing from 2016 to 2020. Confirmatory assay was applied in anti-HIV positive samples by Nanjing Municipal Center for Disease Control and Prevention. The prevalence of TTI was calculated and the trend of disease was analyzed under different demographic groups.
Results: The total positive rate of TTI in blood donors was 0.49% (2 411/487 120), in which the overall seroprevalence rate of HBsAg, anti-HCV, anti-HIV and anti-TP was 0.23%, 0.09%, 0.01% and 0.16%, respectively. The overall prevalence of HIV and TP remained relatively steady (P>0.05), whereas HBV and HCV decreased year by year (P<0.05). The prevalence of TTI was higher among people with lower education level, high age group and first-time blood donation.
Conclusion: The prevalence of TTI among voluntary blood donors in Nanjing is at a low level from 2016 to 2020, but the risk still exists. The recruitment of regular donors and the improvement of blood screening technology can effectively reduce the risk of TTI.
题目: 2016-2020年南京市无偿献血人群HIV/HBV/HCV/TP血清流行病学调查.
目的: 统计近5年南京市无偿献血人群经血传播病原体感染（TTI）情况，为献血者招募和血液筛查策略的制定与更新提供数据支持。.
方法: 对2016-2020年南京市487 120名献血者的标本进行HIV/HBV/HCV/TP ELISA双试剂血清学标志物检测；将抗-HIV筛查阳性样本送至南京市疾控中心进行抗体确证实验；统计TTI血清学流行率并分析不同献血者人口特征下疾病流行趋势。.
结果: 献血者TTI血清学总阳性率为0.49%（2 411/487 120），其中HBsAg、抗-HCV、抗-HIV、抗-TP阳性率分别为0.23%、0.09%、0.01%、0.16%。HIV和TP流行率保持相对稳定（P>0.05），而HBV和HCV流行率总体呈逐年下降趋势（P<0.05）。TTI在受教育水平较低、高年龄段、首次献血人群中流行率较高。.
结论: 2016-2020年南京市无偿献血人群TTI流行率总体处于较低水平，但TTI风险仍持续存在，固定献血者的招募以及血液筛查技术的提升可以有效降低TTI风险。.
Keywords: hepatitis B virus; hepatitis C virus; human immunodeficiency virus; treponema pallidum; volunteer blood donor.