Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma

Head Neck. 2022 Nov;44(11):2505-2512. doi: 10.1002/hed.27161. Epub 2022 Aug 4.

Abstract

Background: To analyze the relationship between the transcriptional expression of lactate dehydrogenase A (LDHA) and the disease control in patients with a head and squamous cell carcinoma (HNSCC).

Methods: We determined the transcriptional expression of LDHA in 110 HNSCC patients treated with surgery.

Results: Five-year disease-free survival for patients with a high transcriptional expression of LDHA (n = 51) was 39.2% (95% confidence interval [CI]: 25.3%-53.1%), and for patients with a low expression (n = 59), it was 63.6% (95% CI: 51.1%-76.1%) (p = 0.004). According to the results of a multivariate analysis, patients with a high transcriptional expression of LDHA had a 3.4-fold increased risk of tumor recurrence. Patients with a high transcriptional expression of LDHA tended to show a higher intensity of immunohistochemical expression of LDHA at the tumor cells (p = 0.086).

Conclusion: In HNSCC patients treated with surgery, a high transcriptional expression of LDHA was associated with a significant decrease in disease-free survival.

Keywords: LDHA: head and neck squamous cell carcinoma; Warburg effect; biomarker; lactate dehydrogenase A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Squamous Cell* / genetics
  • Carcinoma, Squamous Cell* / metabolism
  • Carcinoma, Squamous Cell* / surgery
  • Head and Neck Neoplasms* / genetics
  • Head and Neck Neoplasms* / surgery
  • Humans
  • L-Lactate Dehydrogenase / metabolism
  • Lactate Dehydrogenase 5
  • Neoplasm Recurrence, Local / genetics
  • Prognosis
  • Squamous Cell Carcinoma of Head and Neck / genetics

Substances

  • L-Lactate Dehydrogenase
  • Lactate Dehydrogenase 5