Retinitis pigmentosa (RP) is the commonest inherited retinal dystrophy. It is characterized by progressive photoreceptor degeneration and cell death and ongoing neuronal and vascular impairment. In recent years, pathophysiological alterations of the choroid have begun to be appreciated in RP. Thus, representing a potential diagnostic and therapeutic biomarker. In particular, choroidal thickness and the choroidal vascularity index can be used to understand the pathogenesis of disease and evaluate new therapeutic possibilities. Photoreceptor changes seen in eyes with RP are directly correlated to a decrease of choroidal flow, leading to a strong association between relative choroidal ischemia and visual impairment. In this review we analyse the literature on choroidal thickness and choroidal vascularity index in patients with RP and assess whether these markers may reflect progression of disease from an anatomical and functional point of view.
摘要: 视网膜色素变性 (RP) 是最常见的遗传性视网膜营养不良。其特征是光感受器进行性退行性变性、细胞凋亡以及持续的神经元和血管损伤。近年来, RP的脉络膜病理生理变化开始得到重视。脉络膜病理生理相关的标记物是RP的潜在诊断和治疗的生物标记物。特别是, 脉络膜厚度和脉络膜血管指数可用于了解疾病的发病机制和评估新治疗的可能性。RP患者光感受器变化与脉络膜血流降低直接相关, 导致脉络膜相对缺血和视力损害之间具有显著正相关性。在该综述中, 我们分析了RP患者脉络膜厚度和脉络膜血管指数的相关文献, 并从解剖和功能角度评估这些标志物是否可以反映疾病的进展。.
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