Taming glutathione potentiates metallodrug action

Curr Opin Chem Biol. 2022 Dec:71:102213. doi: 10.1016/j.cbpa.2022.102213. Epub 2022 Oct 4.

Abstract

Metallodrugs that are redox sensitive or have labile coordination sites are particularly susceptible to inhibition by glutathione (GSH) and other endogenous thiols. Because GSH is an essential antioxidant, strategies to prevent thiol deactivation must consider their potential effects on normal cellular functions. In this short review, we describe general approaches for taming glutathione in metallodrug therapy and discuss their strengths and limitations. We also offer our perspectives on developing practical solutions that are effective and clinically relevant.

Keywords: Drug resistance; Glutathione; Metallodrugs; Metals in medicine; Toxicity.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Antioxidants / pharmacology
  • Glutathione* / metabolism
  • Oxidation-Reduction
  • Sulfhydryl Compounds* / pharmacology

Substances

  • Glutathione
  • Sulfhydryl Compounds
  • Antioxidants