Triterpenoid Saponins from the Fruits of Symplocos lucida as β-Glucuronidase Inhibitors

Reina Higashi; Emi Ohta; Hisashi Ômura; Mylene M Uy; Shinji Ohta

doi:10.1002/cbdv.202200774

Triterpenoid Saponins from the Fruits of Symplocos lucida as β-Glucuronidase Inhibitors

Chem Biodivers. 2022 Nov;19(11):e202200774. doi: 10.1002/cbdv.202200774. Epub 2022 Oct 28.

Authors

Reina Higashi¹, Emi Ohta¹, Hisashi Ômura¹, Mylene M Uy², Shinji Ohta¹

Affiliations

¹ Graduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan.
² Department of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City, 9200, Philippines.

PMID: 36205219
DOI: 10.1002/cbdv.202200774

Abstract

A new triterpenoid saponin and five known ones were isolated from the fruits of Symplocos lucida (Thunb.) Siebold & Zucc. Their structures were determined based on the results of spectroscopy analysis, chemical conversions, and X-ray crystallographic analyses. The β-glucuronidase-inhibitory effects of the isolated and semi-synthesized triterpenoid saponins were also examined.

Keywords: Symplocaceae; Symplocos lucida; fruit; triterpenoid saponin; β-glucuronidase inhibitor.

MeSH terms

Enzyme Inhibitors
Fruit / chemistry
Molecular Structure
Saponins* / chemistry
Triterpenes* / chemistry

Substances

beta-glucuronidase inhibitor
Saponins
Triterpenes
Enzyme Inhibitors

Abstract

MeSH terms

Substances

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