Remote diffusion-weighted imaging lesions and blood pressure variability in primary intracerebral hemorrhage

Xuhua Xu; Shuangshuang Peng; Yanli Zhou; Jiawen Li; Lusha Tong; Feng Gao

doi:10.3389/fneur.2022.950056

Remote diffusion-weighted imaging lesions and blood pressure variability in primary intracerebral hemorrhage

Front Neurol. 2022 Sep 20:13:950056. doi: 10.3389/fneur.2022.950056. eCollection 2022.

Authors

Xuhua Xu^{1

2}, Shuangshuang Peng^{1

3}, Yanli Zhou^{1

3}, Jiawen Li¹, Lusha Tong¹, Feng Gao¹

Affiliations

¹ Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Department of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
³ Department of Neurology, Taizhou First People's Hospital, Taizhou, China.

Abstract

Objective: The aim of this study was to examine the association between remote diffusion-weighted imaging lesions (R-DWILs) and blood pressure variability (BPV) in patients with primary intracerebral hemorrhage (ICH).

Methods: We conducted a retrospective review of a consecutive cohort of 375 patients with primary ICH within 24 h onset. R-DWILs were defined as hyperintensity lesions in DWI remote from the hematoma. Blood pressure recordings were extracted up to 24 h post-admission. BPV was measured using SD, coefficient of variation (CV), and successive variation (SV).

Results: Remote DWI lesions were detected in 65 (17.3%) primary ICH patients. In multivariable logistic regression analysis, parameters of BPV were independently associated with R-DWILs, and the results remained consistent after being adjusted with mean SBP. SD, CV, and SV values in the highest quintile, showed 3- to 8-fold increased risk of R-DWILs, compared with the lowest quintile. ΔSBP demonstrated a significant difference in 2 different predictive models. Max SBP only dictated a significant difference in model 1. Mean SBP, admission SBP, and min SBP, failed to present an association with R-DWILs in model 1 or model 2.

Conclusion: Our results provided additional evidence that BPV is associated with the development of R-DWILs in primary ICH.

Keywords: blood pressure; coefficient of variation; intracerebral hemorrhage; remote DWI lesions; standard deviation; successive variation.