Proteomic insights into SARS-CoV-2 infection mechanisms, diagnosis, therapies and prognostic monitoring methods

Front Immunol. 2022 Sep 20:13:923387. doi: 10.3389/fimmu.2022.923387. eCollection 2022.

Abstract

At the end of 2019, the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, seriously damaged world public health security. Several protein markers associated with virus infection have been extensively explored to combat the ever-increasing challenge posed by SARS-CoV-2. The proteomics of COVID-19 deepened our understanding of viral particles and their mechanisms of host invasion, providing us with information on protein changes in host tissues, cells and body fluids following infection in COVID-19 patients. In this review, we summarize the proteomic studies of SARS-CoV-2 infection and review the current understanding of COVID-19 in terms of the quantitative and qualitative proteomics of viral particles and host entry factors from the perspective of protein pathological changes in the organism following host infection.

Keywords: COVID-19; SARS-CoV-2; protein biomarker; proteomics; virus infection.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • COVID-19 Testing
  • COVID-19*
  • Humans
  • Pandemics
  • Peptidyl-Dipeptidase A / metabolism
  • Prognosis
  • Proteomics
  • SARS-CoV-2

Substances

  • Peptidyl-Dipeptidase A
  • Angiotensin-Converting Enzyme 2