SPIN(DLY)-OFF: A tale of conformational change to control DYNEIN

João Barbosa; Claudio E Sunkel; Carlos Conde

doi:10.1083/jcb.202209063

SPIN(DLY)-OFF: A tale of conformational change to control DYNEIN

J Cell Biol. 2022 Nov 7;221(11):e202209063. doi: 10.1083/jcb.202209063. Epub 2022 Oct 6.

Authors

João Barbosa^{1

2}, Claudio E Sunkel^{1

2

3}, Carlos Conde^{1

2}

Affiliations

¹ Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal.
² Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
³ Instituto de Ciência Biomédica de Abel Salazar, Universidade do Porto, Porto, Portugal.

Abstract

Barbosa et al. discuss work by Mussachio and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202206131) finding that conformational changes in the DYNEIN adaptor SPINDLY can precisely control DYNEIN activation at kinetochores.

Publication types

Comment

MeSH terms

Cell Cycle Proteins* / metabolism
Cell Division*
Dyneins* / metabolism
Kinetochores / metabolism
Spindle Apparatus* / metabolism

Substances

Cell Cycle Proteins
Dyneins