Abstract
Molecular network analysis of Streptomyces sp. CMB-MW079 detected rare phosphorylated natural products. Miniaturized cultivation profiling (MATRIX) established optimal conditions for the production, isolation, and identification of the polyketide δ-lactone phoslactomycin E (1) and new ester homologues, phoslactomycins J and K (2 and 3), as well as unprecedented heterocyclic analogues, the tetrahydrofuran cyclolactomycins A-D (4-7) and γ-lactone isocyclolactomycins A-C (8-10). We propose a biogenetic relationship linking these cometabolites with the known lactomycins A-C which were tentatively identified as minor cometabolites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Australia
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Biological Products* / chemistry
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Biological Products* / isolation & purification
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Biological Products* / pharmacology
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Cell Line, Tumor
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Esters / chemistry
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Furans / chemistry
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Humans
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Lactones* / chemistry
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Lactones* / isolation & purification
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Lactones* / pharmacology
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Molecular Structure
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Organophosphorus Compounds* / chemistry
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Organophosphorus Compounds* / isolation & purification
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Organophosphorus Compounds* / pharmacology
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Polyketides* / chemistry
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Polyketides* / isolation & purification
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Polyketides* / pharmacology
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Streptomyces* / chemistry
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Streptomyces* / metabolism
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Wasps* / microbiology
Substances
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Biological Products
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Esters
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Furans
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Lactones
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Organophosphorus Compounds
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Polyketides