The role of DDX46 in breast cancer proliferation and invasiveness: A potential therapeutic target

Cell Biol Int. 2023 Jan;47(1):283-291. doi: 10.1002/cbin.11930. Epub 2022 Oct 6.

Abstract

DDX46, a member of DEAD-box (DDX) proteins, is associated with various cancers, while its involvement in the pathogenesis of breast cancer hasn't been reported so far. The study demonstrated the overexpression of DDX46 in human breast cancer cells and tissue samples, and correlated with high histological grade and lymph node metastasis. Downregulation of DDX46 in the breast cancer cell lines inhibited their proliferation and invasiveness in vitro. Furthermore, the growth of MDA-MB-231 xenografts was suppressed in nude mice by DDX46 knockingdown. Taken together, our findings suggest that DDX46 is an oncogenic factor in human breast cancer, and a potential therapeutic target.

Keywords: DDX46 protein; breast neoplasms; cell proliferation; downregulation; neoplasm invasiveness.

MeSH terms

  • Animals
  • Breast Neoplasms* / genetics
  • Breast Neoplasms* / metabolism
  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation* / genetics
  • DEAD-box RNA Helicases* / genetics
  • DEAD-box RNA Helicases* / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MCF-7 Cells
  • Mice
  • Mice, Nude
  • Neoplasm Invasiveness / genetics
  • Ribonucleoprotein, U2 Small Nuclear / genetics
  • Ribonucleoprotein, U2 Small Nuclear / metabolism

Substances

  • DDX46 protein, human
  • DEAD-box RNA Helicases
  • Ribonucleoprotein, U2 Small Nuclear