Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China

Xin He; RuLin Ma; Yu Li; Haixia Wang; YiZhong Yan; YiDan Mao; ShengYu Liao; XueYing Sun; ShuXia Guo; Heng Guo

doi:10.1155/2022/4632087

Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China

Int J Hypertens. 2022 Sep 26:2022:4632087. doi: 10.1155/2022/4632087. eCollection 2022.

Authors

Xin He^{1

2}, RuLin Ma¹, Yu Li¹, Haixia Wang¹, YiZhong Yan¹, YiDan Mao¹, ShengYu Liao¹, XueYing Sun¹, ShuXia Guo¹, Heng Guo^{1

2}

Affiliations

¹ Department of Public Health, Shihezi University School of Medicine, North 2th Road, Shihezi 832000, Xinjiang, China.
² NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China.

Abstract

Objective: This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. Then, we analyzed the effect of MTHFR 677C > T polymorphism on the association between the above miRNA and H-type hypertension.

Method: In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and then stratified according to the C677T polymorphism to analyze the relationship between target miRNAs and HHcy.

Results: The expression of miR-21/-29 in the hypertension group was higher than the normal group (P < 0.001). And the expression of miR-199 was higher in the hcy group than in the normal group (P < 0.001). In the CC and CT genotypes of MTHFR 677C > T, the expression of miR-21 was lower in the HHcy patients than in the normal individuals (P = 0.005 and P = 0.001) and miR-199 was significantly higher in the HHcy patients than in the normal ones (P = 0.002 and P = 0.048). No such difference was found in the TT genotype. Logistic regression analysis showed that after adjusting for sex, age, BMI, systolic blood pressure, diastolic blood pressure, and MTHFRC677 T gene polymorphism, miR-21 was negatively correlated with hcy (OR = 0.222, 95% CI (0.101-0.485), P < 0.001) and miR-199 was positively correlated with hcy (OR = 1.823,95%CI (1.272∼2.614), P = 0.001).

Conclusion: miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia. And these three miRNAs may serve as biomarkers to provide clues to the potential pathogenesis of H-type hypertension.