Recent advances in photothermal therapy-based multifunctional nanoplatforms for breast cancer

Jingjun Sun; Haiyan Zhao; Weixuan Xu; Guo-Qin Jiang

doi:10.3389/fchem.2022.1024177

Recent advances in photothermal therapy-based multifunctional nanoplatforms for breast cancer

Front Chem. 2022 Sep 19:10:1024177. doi: 10.3389/fchem.2022.1024177. eCollection 2022.

Authors

Jingjun Sun^{1

2}, Haiyan Zhao³, Weixuan Xu², Guo-Qin Jiang¹

Affiliations

¹ Department of Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China.
² Department of Breast Surgery, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China.
³ Department of Breast Surgery, Shanghai Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.

Abstract

Breast cancer (BC) is one of the most common cancers in women worldwide; however, the successful treatment of BC, especially triple-negative breast cancer (TNBC), remains a significant clinical challenge. Recently, photothermal therapy (PTT), which involves the generation of heat under irradiation to achieve photothermal ablation of BC with minimal invasiveness and outstanding spatial-temporal selectivity, has been demonstrated as a novel therapy that can overcome the drawbacks of chemotherapy or surgery. Significantly, when combining PTT with chemotherapy and/or photodynamic therapy, an enhanced synergistic therapeutic effect can be achieved in both primary and metastatic BC tumors. Thus, this review discusses the recent developments in nanotechnology-based photothermal therapy for the treatment of BC and its metastasis to provide potential strategies for future BC treatment.

Keywords: NIR dye; accurate therapy; breast cancer; combination therapeutic strategy; photothermal therapy; targeted delivery platform.

Publication types

Review