Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain

Damilare Emmanuel Rotimi; Goodnews Mavoghenegbero Ben-Goru; Ikponmwosa Owen Evbuomwan; Tobiloba Christiana Elebiyo; Mohammed Alorabi; Abdullah Farasani; Gaber El-Saber Batiha; Oluyomi Stephen Adeyemi

doi:10.1155/2022/9470178

Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain

Evid Based Complement Alternat Med. 2022 Sep 26:2022:9470178. doi: 10.1155/2022/9470178. eCollection 2022.

Authors

Affiliations

¹ SDG 03 Group-Good Health & Well-Being, Landmark University, Omu-Aran 251101, Kwara State, Nigeria.
² Department of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran 251101, Nigeria.
³ Department of Microbiology, Cellular Parasitology Unit, College of Pure and Applied Sciences, Landmark University, PMB 1001, Omu-Aran 251101, Nigeria.
⁴ Department of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
⁵ Department of Medical Laboratory Technology, Biomedical Research Unit, Medical Research Center, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia.
⁶ Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, Egypt.
⁷ Laboratory of Sustainable Animal Environment, Graduate School of Agricultural Science, Tohoku University, 232-3 Yomogida, Naruko-Onsen, Osaki, Miyagi 989-6711, Sendai, Japan.

Abstract

The study investigated the effects of Zingiber officinale root and Vernonia amygdalina leaf on the brain redox status of Wistar rats. Twenty-four (24) rats weighing 160 ± 20 g were randomly assigned into four (4) groups, each with six (6) rats. Animals in Group 1 (control) were orally administered distilled water (1 mL), while the test groups were orally administered 5 mg/mL of either Z. officinale, V. amygdalina infusion, or a combination of both, respectively, for 7 days. The rats were sacrificed at the end of treatments and blood and tissue were harvested and prepared for biochemical assays. Results showed that administration of V. amygdalina and Z. officinale, as well as their coadministration, reduced the levels of malondialdehyde (MDA), nitric oxide (NO), acetylcholinesterase (AChE), and myeloperoxidase (MPO) in rat brain tissue compared with the control group. Conversely, coadministration of V. amygdalina and Z. officinale increased the levels of reduced glutathione (GSH) in rat brain tissue compared with the control group. However, the administration of the infusions singly, as well as the combination of both infusions, did not have any effect on the rat brain levels of glutathione peroxidase (GPx) and catalase (CAT) antioxidant enzymes compared to the control. Taken together, the findings indicate that the V. amygdalina and Z. officinale tea infusions have favorable antioxidant properties in the rat brain. The findings are confirmatory and contribute to deepening our understanding of the health-promoting effects of V. amygdalina and Z. officinale tea infusions.