Stabilizing Tetrameric Structure of Ryanodine Receptor Cures Lethal Arrhythmia in Heart Failure

Circ Arrhythm Electrophysiol. 2022 Oct;15(10):e011220. doi: 10.1161/CIRCEP.122.011220. Epub 2022 Oct 5.

Authors

Shigeki Kobayashi¹, Takeshi Yamamoto², Yasuhiro Yoshiga¹, Takayuki Okamura¹, Reo Kawano³, Masafumi Yano¹

Affiliations

¹ Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan (S.K., Y.Y., T.O., M.Y.).
² Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Ube, Japan (T.Y.).
³ Innovation Center for Translational Research, National Center for Geriatrics and Gerontology, Aichi, Japan (R.K.).

PMID: 36197726
DOI: 10.1161/CIRCEP.122.011220

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Arrhythmias, Cardiac
Calcium / metabolism
Calcium Signaling
Heart Failure* / therapy
Humans
Ryanodine
Ryanodine Receptor Calcium Release Channel* / metabolism

Substances

Ryanodine Receptor Calcium Release Channel
Calcium
Ryanodine