Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis

Cancer Discov. 2022 Oct 5;12(10):2234-2236. doi: 10.1158/2159-8290.CD-22-0846.

Abstract

Transgenic knockin mice expressing a common loss-of-function mutation in human TET2 exhibit aging-related accelerated myeloid leukemia development and skewing of myelopoiesis toward the production of proinflammatory MHC-IIhi monocytes that may contribute to disease. See related article by Yeaton et al., p. 2392 (2).

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Carcinogenesis
  • DNA-Binding Proteins / genetics
  • Dioxygenases* / genetics
  • Humans
  • Inflammation / genetics
  • Leukemia* / genetics
  • Mice
  • Monocytes
  • Mutation
  • Neoplasms*
  • Proto-Oncogene Proteins / genetics

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Dioxygenases
  • TET2 protein, human
  • Tet2 protein, mouse